Rosanne Spolski Selected Research

Interleukin-21 Receptors

12/2021	MicroRNA-30b Is Both Necessary and Sufficient for Interleukin-21 Receptor-Mediated Angiogenesis in Experimental Peripheral Arterial Disease.
4/2016	Endothelial interleukin-21 receptor up-regulation in peripheral artery disease.
1/2016	Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice.
5/2015	Loss of interleukin-21 receptor activation in hypoxic endothelial cells impairs perfusion recovery after hindlimb ischemia.
7/2013	Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells.
3/2013	The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells.
11/2012	Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.
2/2012	IL-21 promotes the pathologic immune response to pneumovirus infection.
2/2009	A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice.
5/2007	The molecular basis of IL-21-mediated proliferation.

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Rosanne Spolski Research Topics

Disease

15	Neoplasms (Cancer) 01/2022 - 12/2003
10	Autoimmune Diseases (Autoimmune Disease) 10/2018 - 11/2004
7	Infections 01/2019 - 03/2011
6	Inflammation (Inflammations) 01/2021 - 03/2009
5	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 01/2017 - 11/2002
3	Virus Diseases (Viral Diseases) 10/2018 - 02/2012
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 03/2009 - 11/2004
2	Peripheral Arterial Disease 12/2021 - 04/2016
2	Ischemia 12/2021 - 05/2015
2	Melanoma (Melanoma, Malignant) 01/2021 - 12/2003
2	Atopic Dermatitis (Atopic Eczema) 01/2021 - 08/2011
2	Asthma (Bronchial Asthma) 01/2021 - 08/2011
2	Experimental Arthritis 01/2016 - 09/2008
2	B-Cell Lymphoma (Lymphoma, B Cell) 05/2015 - 03/2014
2	Hypersensitivity (Allergy) 06/2008 - 09/2004
2	Experimental Melanoma 01/2005 - 12/2003
1	Cushing Syndrome 01/2022
1	Adenoma (Adenomas) 01/2022
1	Lymphopenia (Lymphocytopenia) 01/2022
1	Necrosis 12/2021
1	Bacterial Infections (Bacterial Infection) 11/2016
1	Rheumatoid Arthritis 01/2016
1	Endometrial Neoplasms (Endometrial Cancer) 09/2015
1	Leukemia 05/2015
1	Eosinophilia 11/2014
1	Colitis 03/2013
1	Multiple Sclerosis 11/2012
1	Pneumovirus Infections 02/2012
1	Liver Diseases (Liver Disease) 03/2011
1	Hepatitis B 03/2011
1	Persistent Infection 03/2011
1	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 02/2009
1	T-Cell Lymphoma (Lymphoma, T Cell) 01/2008
1	Lymphoma (Lymphomas) 01/2008
1	Fibrosarcoma 12/2003
1	Renal Cell Carcinoma (Grawitz Tumor) 12/2003
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 12/2003
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/2003
1	Dysgammaglobulinemia 11/2002

Drug/Important Bio-Agent (IBA)

23	interleukin-21 (interleukin 21)IBA 01/2022 - 11/2002
12	CytokinesIBA 01/2021 - 11/2002
11	Interleukin-21 ReceptorsIBA 12/2021 - 09/2005
6	Interleukin-2 (IL2)IBA 01/2020 - 11/2002
5	AntigensIBA 01/2021 - 07/2003
5	Cytokine Receptors (Cytokine Receptor)IBA 01/2017 - 11/2002
4	Thymic Stromal LymphopoietinIBA 01/2021 - 08/2011
4	Interleukin-15 (Interleukin 15)IBA 01/2017 - 11/2002
4	Interleukin-4 (Interleukin 4)IBA 01/2017 - 11/2002
3	InterleukinsIBA 01/2017 - 12/2003
3	Interleukin-10 (Interleukin 10)IBA 02/2013 - 01/2010
3	Proteins (Proteins, Gene)FDA Link 02/2012 - 09/2005
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 10/2009 - 07/2003
2	Interleukin-9 (Interleukin 9)IBA 01/2017 - 03/2014
2	RNA (Ribonucleic Acid)IBA 09/2015 - 08/2015
2	Interleukin-2 Receptors (IL 2 Receptor)IBA 05/2007 - 09/2005
1	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2022
1	GlucocorticoidsIBA 01/2022
1	LigandsIBA 12/2021
1	MyoglobinIBA 12/2021
1	Chimeric Antigen ReceptorsIBA 01/2021
1	Interleukin-7 (Interleukin 7)IBA 01/2017
1	Complement System Proteins (Complement)IBA 11/2016
1	chenodeoxycholate sulfate conjugate (CDCS)IBA 08/2015
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 05/2015
1	bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA 05/2015
1	Pharmaceutical PreparationsIBA 11/2014
1	Antiviral Agents (Antivirals)IBA 05/2014
1	InterferonsIBA 03/2013
1	Chemokine CXCL1IBA 02/2012
1	VaccinesIBA 07/2009
1	AutoantibodiesIBA 02/2009
1	Tyrosine (L-Tyrosine)FDA Link 01/2008
1	Deoxyribonuclease I (Nickase)IBA 09/2004
1	DNA (Deoxyribonucleic Acid)IBA 12/2003
1	Immunoglobulin G (IgG)IBA 11/2002

Therapy/Procedure

3	Therapeutics 01/2022 - 06/2008
3	Immunotherapy 01/2021 - 12/2003